The 45-room, upscale, family-owned Hotel Monna Lisa is set in a 14th century building that was originally a convent, then a palace, and finally a hotel in the 1950s. The architecture and decor are extraordinary, featuring the family's private collection of antique furniture and art, some by great masters. Rooms are classically decorated with silk and antiques, but vary in size, with older bathrooms. The Monna Lisa embodies Renaissance Florence; this hotel is a solid pick for guests interested in the city's culture and history.